Victoria Nuland may be the latest reason to disrupt their direction, but Pakistan has a tendency to shoot itself in the foot more often than not.
The so-called "Indian hegemony" is an imaginary construct in the minds of the Pakistani Army, who needs a perpetual reason for justifying its overly large share in the Pakistani federal budget.
When it's not sending terrorists into India, then it's fighting internally and attempting to win elections. All that needs money, money from the budget. And anyone that comes in the way, like Imran Khan did, makes them upset.